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EE Chapter 64 Parkinson’s Disease Q&A (1 OF 43) Sample Questions

1. Why should Catecholamine Methyl Transferase (COMT) inhibitors (Tolcapone, Entacapone) always have to be used with Levodopa?

A. COMT inhibitor decrease metabolism of Levodopa to 3-O-methyldopa.
B. COMT inhibitors have synergistic action with Levodopa.
C. COMT inhibitors have additive action with Levodopa.
D. COMT inhibitors should not combine with Levodopa.
E. None of the above

Answer

Ans: A

Strategic thinking:
1. Read the question. You are asked to determine the rationale of combining COMTi with an antiparkinson agent.
2. Questions like these are simply asking you of the mechanism of action of a drug but stated differently. COMT inhibitors on their own do not have effect on Parkinson’s disease but it is rational to combine them with antiParkinson’s agent because they protect the main drug from being degraded by the COMT, thus allowing the main drug to be in sufficient level in the body.
3. Thus, the correct answer is A.

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